According to the Symantec Internet Security Threat Report (ISTR), 400 million new variants of malware were created in 2011, which is an average of 33 million new variants of malware a month, or an average of one million new variants a day.
Source: http://www.symantec.com/connect/blogs/malware-authors-using-new-techniques-evade-automated-threat-analysis-systems Symantec Security Response